m-Chloroperbenzoic acid → HCID 59464117、化合物

HRID 1478886ノート

反応式

HRID 1478886 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.C1C=C(Cl)C=C(C(OO)=[O:21])C=1>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][N+:7]=1[O-:21]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 53419528Methyl 2-(6-chloropyridin-3-yl)acetate

生成物 1

HCID 59464117HCID 59464117、化合物収率 92.1%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To methyl 2-(6-chloropyridin-3-yl)acetate (2.5 g) in DCM (100 mL) was added mCPBA (4.6 g). The resulting reaction mixture was stirred at room temperature for 4 hr. The organic phase was washed with sat. NaHCO3, dried over Na2SO4, and concentrated. The crude product was purified by flash chromatography to afford the title product (2.5 g).

後処理

  1. customThe resulting reaction mixture
  2. washThe organic phase was washed with sat. NaHCO3
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customThe crude product was purified by flash chromatography

出典と根拠

ORDレコード
ord-b175f0a40b0348f3a7895e9696e78964
出典データセット
uspto-grants-2016_08
特許番号
US09403850B2

反応ノート

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