Methyl iodide → 3-Bromo-6-methoxypicolinonitrile
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5](=[O:8])[NH:4][C:3]=1[C:9]#[N:10].I[CH3:12]>C1(C)C=CC=CC=1.C(=O)([O-])[O-].[Ag+2]>[Br:1][C:2]1[C:3]([C:9]#[N:10])=[N:4][C:5]([O:8][CH3:12])=[CH:6][CH:7]=1参加物
5
実験手順
A solution of 3-bromo-6-oxo-1,6-dihydropyridine-2-carbonitrile (from Example 15/Step 2) (1.0 eq.), silver carbonate (1.3 eq.), and iodomethane (1.2 eq.) in toluene (0.2 M) was stirred in the dark at room temperature overnight. The solvent was concentrated en vacuo, and the resulting residue was purified by a COMBIFLASH® system (ISCO) using 0-80% ethyl acetate in hexane to give 3-bromo-6-methoxypicolinonitrile.
後処理
- customdark at room temperature
- customovernight
- concentrationThe solvent was concentrated en vacuo
- customthe resulting residue was purified by a COMBIFLASH® system (ISCO)
出典と根拠
- ORDレコード
- ord-e3e696424e214f24b0cf2023ebf5f8aa
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09408907B2
反応ノート
読み込み中…