p-Toluenesulfonic acid → HCID 89580873、化合物
反応式
O1CCCCC1[O:7][CH2:8][CH2:9][CH:10]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)[CH3:11].C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[OH:7][CH2:8][CH2:9][CH:10]([C:12]1[CH:13]=[CH:14][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:20][CH:21]=1)[CH3:11]参加物
4
実験手順
To the solution of methyl 4-(4-(tetrahydro-2H-pyran-2-yloxy)butan-2-yl)benzoate (501.8 mg 1.72 mmol) in methanol (60 mL) was added p-toluenesulfonic acid (592 mg, 3.44 mmol). the solution was stirred for 12 hours, then the solvent was remove and dissolved in dichloromethane (50 ml) and washed water, dried with sodium sulfate, concentrated to give methyl 4-(4-hydroxybutan-2-yl)benzoate (354 mg, 99%).
後処理
- customthe solvent was remove
- dissolutiondissolved in dichloromethane (50 ml)
- washwashed water
- dry with materialdried with sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-aacbe58e2ccc4079936916b77d3eef8e
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409865B2
反応ノート
読み込み中…