Sodium Hydroxide → 1-[Methyl-(4-fluorophenyl)sulfonyl-amino]cyclopropanecarboxylic acid
反応式
[CH3:1][N:2]([S:10]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[C:3]1([C:6]([O:8]C)=[O:7])[CH2:5][CH2:4]1.[OH-].[Na+]>O1CCOCC1>[CH3:1][N:2]([S:10]([C:13]1[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=1)(=[O:12])=[O:11])[C:3]1([C:6]([OH:8])=[O:7])[CH2:5][CH2:4]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
A solution of 14A (1.3 g, 4.52 mmol) in dioxane (40 mL) was added with 10% NaOH aq. solution (20 mL) and the mixture was heated at 50° C. overnight. The organic solvent was removed under reduced pressure and the aqueous phase was acidified with 10% HCl. The solid formed was collected by filtration, washed with water (2×20 mL) and dried to afford 15A as white solid (1.0 g, 81% yield). 1HNMR (DMSO, 200 MHz) δ 1.40 (bs, 4H), 2.91 (s, 3H), 7.42 (m, 2H), 7.80 (m, 2H), 12.60 (bs, 1H).