反応式
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[F:18][C:19]([F:29])([F:28])[CH:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1>>[F:29][C:19]([F:18])([F:28])[CH:20]([NH:27][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][CH:15]2[CH2:17][CH2:16]2)[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1参加物
3
実験手順
The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 2,2,2-Trifluoro-1-pyridin-2-yl-ethylamine (CAN 503173-14-6) as starting materials and isolated (17.2 mg, 29%) as colorless oil; MS (ESI, m/z): 392.5 (M+H+).
後処理
- customisolated (17.2 mg, 29%) as colorless oil
出典と根拠
- ORDレコード
- ord-906dd0849a1f46b285bae61897e1a53c
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409866B2
関連ノート
読み込み中…