1-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1) → 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxy-cyclopentylmethyl)-amide

HRID 1480112

反応式

HRID 1480112 の反応式
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.Cl.[NH2:19][CH2:20][C:21]1([OH:26])[CH2:25][CH2:24][CH2:23][CH2:22]1>>[OH:26][C:21]1([CH2:20][NH:19][C:10]([C:7]2[CH:6]=[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)[C:4]([CH:1]3[CH2:2][CH2:3]3)=[CH:9][N:8]=2)=[O:12])[CH2:25][CH2:24][CH2:23][CH2:22]1

参加物

3

反応物 2

HCID 211096931-(Aminomethyl)cyclopentan-1-ol--hydrogen chloride (1/1)HCID 902038095-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

生成物 1

HCID 762842215-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (1-hydroxy-cyclopentylmethyl)-amide

実験手順

The title compound was synthesized in analogy to Example 54, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and 1-(aminomethyl)cyclopentanol hydrochloride (CAN 76066-27-8) as starting materials and isolated (71 mg, 63%) as a white solid; MS (ESI, m/z): 331.0 (M+H+).

後処理

  1. customisolated (71 mg, 63%) as a white solid

出典と根拠

ORDレコード
ord-a5afc7e1dceb466985df8d139186b165
出典データセット
uspto-grants-2016_08
特許番号
US09409866B2

関連ノート

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