[2-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-carbamic acid benzyl ester → 2-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine

HRID 1480127

反応式

HRID 1480127 の反応式
C(OC(=O)[NH:10][C:11]([CH3:22])([C:16]1[N:20]=[C:19]([CH3:21])[O:18][N:17]=1)[CH2:12][CH:13]1[CH2:15][CH2:14]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[CH:13]1([CH2:12][C:11]([NH2:10])([CH3:22])[C:16]2[N:20]=[C:19]([CH3:21])[O:18][N:17]=2)[CH2:15][CH2:14]1

参加物

5

反応物 2

HCID 90203645[2-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-carbamic acid benzyl esterHCID 178418361HCID 178418361、化合物

生成物 1

HCID 710877912-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethylamine収率 53%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of [2-Cyclopropyl-1-methyl-1-(5-methyl-[1,2,4]oxadiazol-3-yl)-ethyl]-carbamic acid benzyl ester (Example 66d, 540 mg, 1.71 mmol) in ethanol (10 ml) under argon atmosphere was added palladium on charcoal 10% (54.7 mg, 514 μmol). The reaction was stirred at room temperature under a pressure of 2.5 bar hydrogen for 2 hours. The reaction mixture was filtered through a pad celite and the filter cake was washed two times with ethanol. The filtrate was evaporated down to dryness to yield the title compound (163 mg, 53%) as crude yellow oil which was used with any purification. MS (ESI, m/z): 182.2 (M+H+).

後処理

  1. filtrationThe reaction mixture was filtered through a pad celite
  2. washthe filter cake was washed two times with ethanol
  3. customThe filtrate was evaporated down to dryness

出典と根拠

ORDレコード
ord-1eedee4e648f458f98d23c07f2345db9
出典データセット
uspto-grants-2016_08
特許番号
US09409866B2

関連ノート

読み込み中…