Ethyl 2-[3-(benzylamino)-1,1-dioxo-thietan-3-yl]acetate → Ethyl (3-amino-1,1-dioxido-3-thietanyl)acetate
反応式
C([NH:8][C:9]1([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][S:11](=[O:14])(=[O:13])[CH2:10]1)C1C=CC=CC=1>CCO.[Pd]>[NH2:8][C:9]1([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:12][S:11](=[O:14])(=[O:13])[CH2:10]1参加物
4
反応条件
- 温度
- 50 °C
実験手順
To a solution of ethyl 2-[3-(benzylamino)-1,1-dioxo-thietan-3-yl]acetate (example 160b, 0.5 g, 1.68 mmol) in EtOH (12.5 ml) under an argon atmosphere was added palladium on charcoal 10% (w/w 10%) (50.0 mg, 470 μmol). The reaction flask was put under a pressure of 2.5 bar H2 and the reaction mixture was then stirred at 50° C. for 16 hours. Palladium catalyst was removed by filtration over a pad of Celite and the filter cake was washed with ethanol twice. The filtrate was evaporated down to dryness to yield the title compound (350 mg, 100%) as a crude product which was used without any purification. MS (ESI, m/z): 208.1 (M+H+).