化工社化工社 化学情報印刷レポート · 研究参考用
2-Amino-3,3-dimethylbutanenitrile → N-(1-cyano-2,2-dimethyl-propyl)-5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-3,3-dimethylbutanenitrile | HCID 11378465 | — |
| 反応物 | 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid | HCID 90204573 | — |
| 生成物 | N-(1-cyano-2,2-dimethyl-propyl)-5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxamide | HCID 90214975 | — |
反応手順
The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridine-2-carboxylic acid (Example 68a) and 2-Amino-3,3-dimethyl-butyronitrile (CAN 77425-86-6) as starting materials and isolated (2 g, 99%); MS (ESI, m/z): 370.6 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09409866B2 |
| 出典データセット | uspto-grants-2016_08 |
| ORD ID | ord-163dd4bb740f4daea0e622d4614505c3 |
| 出典メモ | uspto-grants-2016_08 |