Methylamine hydrochloride → tert-butyl N-[2-hydroxy-2-methyl-1-(methylcarbamoyl)propyl]carbamate
反応式
[C:1]([O:5][C:6]([NH:8][CH:9]([C:13]([OH:16])([CH3:15])[CH3:14])[C:10](O)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:18][NH2:19]>>[OH:16][C:13]([CH3:15])([CH3:14])[CH:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[C:10](=[O:11])[NH:19][CH3:18]参加物
3
実験手順
The title compound was synthesized in analogy to Example 112e, using 2-tert-Butoxycarbonylamino-3-hydroxy-3-methyl-butyric acid (CAN 105504-72-1) and methanamine hydrochloride as starting materials and isolated (486 mg, 38%); MS (ESI, m/z): 247.2 (M+H+).
後処理
- customisolated (486 mg, 38%)
出典と根拠
- ORDレコード
- ord-4d8a2040576f40389348dad3e3507555
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409866B2
反応ノート
読み込み中…