Sodium hydride → HCID 90203560、化合物

反応式

[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1Cl.[F:9][CH2:10][CH:11]([OH:13])[CH3:12].[H-].[Na+]>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[O:13][CH:11]([CH3:12])[CH2:10][F:9]

参加物

反応物 3

HCID 24758Sodium hydride

HCID 1016711-Fluoropropan-2-ol

HCID 8176963-Bromo-4-chloropyridine

生成物 1

HCID 90203560HCID 90203560、化合物

実験手順

The title compound was synthesized in analogy to Example 108b, using 3-bromo-4-chloropyridine (CAN 36953-42-1), 1-fluoropropan-2-ol (CAN 430-50-2) as starting materials and sodium hydride as reagent. The title compound was isolated (7.55 g, 62%) as a yellow oil; MS (ESI, m/z): 235.9 (M+H+).

後処理

customThe title compound was synthesized in analogy to Example 108b

出典と根拠

ORDレコード: ord-ffb695f3a61c46c8958c9a1240906c37
出典データセット: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09409866B2

反応ノート

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