Sodium Hydroxide → 2-Oxo-2,3-dihydro-1,3-thiazole-5-carboxylic acid

HRID 1480389ノート

反応式

HRID 1480389 の反応式
C[O:2][C:3]1[S:4][C:5]([C:8]([OH:10])=[O:9])=[CH:6][N:7]=1.C[O-].[Na+].[OH-].[Na+]>CO>[O:2]=[C:3]1[NH:7][CH:6]=[C:5]([C:8]([OH:10])=[O:9])[S:4]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 10942334Sodium MethoxideHCID 164948972-Methoxy-1,3-thiazole-5-carboxylic acid

生成物 1

HCID 200616172-Oxo-2,3-dihydro-1,3-thiazole-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

2-Methoxythiazole-5-carboxylic acid (step 1) (45.5 mg, 0.286 mmol) was solubilised in MeOH (2 ml) and treated with 5.4M NaOMe in MeOH (212 μl, 1.143 mmol) followed by 2M NaOH (572 μl, 1.143 mmol). The reaction mixture was refluxed overnight and after cooling to RT, the solvent was evaporated under reduced pressure. The residue was acidified with 6M aqueous hydrochloric acid and aqueous layer extracted with EtOAc. The organics were combined and dried over MgSO4 (anh) filtered and evaporated under reduced pressure resulting in a pale yellow solid.

後処理

  1. temperatureThe reaction mixture was refluxed overnight
  2. customthe solvent was evaporated under reduced pressure
  3. extractionextracted with EtOAc
  4. dry with materialdried over MgSO4 (anh)
  5. filtrationfiltered
  6. customevaporated under reduced pressure
  7. customresulting in a pale yellow solid

出典と根拠

ORDレコード
ord-03721ea365104971b353daf8f98bb2bd
出典データセット
uspto-grants-2016_08
特許番号
US09409895B2

反応ノート

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