Hydrochloric Acid → 2-Hydroxy-1,3-oxazole-5-carboxylic acid

HRID 1480424ノート

反応式

HRID 1480424 の反応式
[O:1]=[C:2]1[NH:6][CH:5]=[C:4]([C:7]([O:9]CC)=[O:8])[O:3]1.O[Li].O.Cl.O1CCOCC1>C1COCC1.O.CO>[O:1]=[C:2]1[NH:6][CH:5]=[C:4]([C:7]([OH:9])=[O:8])[O:3]1

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 168937Lithium hydroxide, monohydrateHCID 46739512Ethyl 2-oxo-2,3-dihydrooxazole-5-carboxylate

生成物 1

HCID 539814232-Hydroxy-1,3-oxazole-5-carboxylic acid

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of ethyl 2-oxo-2,3-dihydrooxazole-5-carboxylate (300 mg, 1.909 mmol) in THF (5 ml) was added LiOH.H2O (352 mg, 8.4 mmol) as a solution in water (5 ml). The mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure. To the residue was added 4M HCl in dioxane (6 ml, 24.0 mmol) and the solid was sonicated for ˜1 minute. The solvent was removed under reduced pressure to afford a yellow solid. The solid was redissolved in MeOH and concentrated under reduced pressure. The solid was dried in the vacuum oven to afford the title compound;

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe solid was sonicated for ˜1 minute
  3. customThe solvent was removed under reduced pressure
  4. customto afford a yellow solid
  5. concentrationconcentrated under reduced pressure
  6. customThe solid was dried in the vacuum oven

出典と根拠

ORDレコード
ord-ce4dc1460c774925a7a1d2c358c6466f
出典データセット
uspto-grants-2016_08
特許番号
US09409895B2

反応ノート

読み込み中…