Sodium Hydroxide → HCID 86722680、化合物

HRID 1480455ノート

反応式

HRID 1480455 の反応式
[NH2:1][CH:2]1[CH2:8][CH:7]2[N:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:4]([CH2:5][CH2:6]2)[CH2:3]1.[C:17](Cl)(=[O:28])[O:18][CH2:19][C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[C:22]([Cl:27])[CH:21]=1.[OH-].[Na+]>C(Cl)Cl>[Cl:26][C:24]1[CH:25]=[C:20]([CH:21]=[C:22]([Cl:27])[CH:23]=1)[CH2:19][O:18][C:17]([NH:1][CH:2]1[CH2:3][CH:4]2[N:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:7]([CH2:6][CH2:5]2)[CH2:8]1)=[O:28]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 133055323,5-Dichlorobenzyl ChloroformateHCID 22570519tert-Butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate

生成物 1

HCID 86722680HCID 86722680、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A reaction mixture comprising of tert-butyl 3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate (210 mg, 0.928 mmol), 3,5-dichlorobenzyl carbonochloridate (222 mg, 0.928 mmol), and sodium hydroxide (4.64 ml, 93 mmol) in DCM (3.1 ml) was stirred at room temperature for 4 hours. The reaction mixture separated and the organic portion dried over MgSO4, filtered and concentrated under reduced pressure. No further purification was carried out and the material was taken on crude to the next step.

後処理

  1. customThe reaction mixture separated
  2. dry with materialthe organic portion dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customNo further purification

出典と根拠

ORDレコード
ord-2a1d1d81d69649968d8a24205b08bc5a
出典データセット
uspto-grants-2016_08
特許番号
US09409895B2

反応ノート

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