Thionyl Chloride → HCID 178521140、化合物

HRID 1480460ノート

反応式

HRID 1480460 の反応式
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([OH:11])=O)[N:3]=[N:2]1.S(Cl)([Cl:14])=O>C(Cl)Cl>[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][CH2:8][C:9]([Cl:14])=[O:11])[N:3]=[N:2]1

参加物

4

反応物 2

HCID 24386Thionyl Chloride2 回HCID 178525383HCID 178525383、化合物

生成物 1

HCID 178521140HCID 178521140、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution/suspension of 4-(1H-1,2,3-triazol-4-yl)butanoic acid (150 mg, 0.967 mmol) in dry DCM (10 mL) was added thionyl chloride (0.847 mL, 11.60 mmol) at RT. After 30 mins some solid still remained so a further 0.4 ml thionyl chloride was added and the reaction mixture allowed to stir at RT for 2 hrs. The reaction mixture was concentrated under reduced pressure to afford the title product which was used in the next step without further purification.

後処理

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-d9d9817ae2ec4bafa63d006f8796184c
出典データセット
uspto-grants-2016_08
特許番号
US09409895B2

反応ノート

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