Formamide → HCID 178497210、化合物

反応式

[NH2:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[C:11](OCC)=[O:12])=[CH:8][CH:7]=[C:6]([C:16]([O:18][CH3:19])=[O:17])[CH:5]=2.C([O-])=O.[NH4+].[CH:24]([NH2:26])=O>O>[OH:12][C:11]1[C:10]2[C:9]3[C:4](=[CH:5][C:6]([C:16]([O:18][CH3:19])=[O:17])=[CH:7][CH:8]=3)[NH:3][C:2]=2[N:1]=[CH:24][N:26]=1

参加物

反応条件

温度: 165 °C

実験手順

In a 100 mL round-bottom flask were added 3-ethyl 6-methyl 2-amino-1H-indole-3,6-dicarboxylate (1.1 g, 4.19 mmol), ammonium formate (0.53 g, 8.39 mmol), and formamide (16.7 mL, 419 mmol) to give a tan suspension which was heated to 165° C. for 12 hours. The mixture was allowed to cool to room temperature and water was added. The resulting precipitate was filtered, air-dried and dried under high vacuum overnight to afford 1.1 g of the title compound. LCMS m/z 244.2 (M+H)+, retention time (on analytical HPLC)=1.51 minutes.