1-Methylpiperazine → 1-(3-Methoxy-4-nitrophenyl)-4-methylpiperazine

HRID 1480878ノート

反応式

HRID 1480878 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH3:12])[CH:3]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>>[CH3:12][O:11][C:4]1[CH:3]=[C:2]([N:17]2[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

参加物

3

反応物 2

HCID 531671-MethylpiperazineHCID 27792505-Fluoro-2-nitroanisole

生成物 1

HCID 567772431-(3-Methoxy-4-nitrophenyl)-4-methylpiperazine

実験手順

The title compound was prepared according to the method described for Preparations 78 and 79 using 4-fluoro-2-methoxy-1-nitrobenzene and 1-methylpiperazine. The residue was purified by silica gel column chromatography eluting with 0-20% MeOH in EtOAc.

後処理

  1. customThe residue was purified by silica gel column chromatography
  2. washeluting with 0-20% MeOH in EtOAc

出典と根拠

ORDレコード
ord-c4e51632a78b430a812bec9d65796c9b
出典データセット
uspto-grants-2016_08
特許番号
US09409907B2

反応ノート

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