Ethanol → 4-Hydroxy-7-phenethyl-isoquinoline-3-carboxylic acid methyl ester

HRID 1481135ノート

反応式

HRID 1481135 の反応式
[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:16]#[C:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH:9]=2)=[O:4].CCO>[Pd].CCOC(C)=O>[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH:9]=2)=[O:4]

参加物

5

反応物 2

HCID 702EthanolHCID 89812978HCID 89812978、化合物

生成物 1

HCID 898128624-Hydroxy-7-phenethyl-isoquinoline-3-carboxylic acid methyl ester収率 569.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 4-hydroxy-7-phenylethynyl-isoquinoline-3-carboxylic acid methyl ester (60 mg, 0.20 mmol), 10% Pd/C (200 mg), EtOH (10 mL) and EtOAc (20 mL) was stirred under H2 atmosphere for 48 h. The resulting mixture was filtered, and the filtrate was concentrated. The residue was purified by column chromatography (0-40% EtOAc/hexanes) to give 350 mg of the title compound. MS: (+) m/z 308.26 (M+1).

後処理

  1. filtrationThe resulting mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by column chromatography (0-40% EtOAc/hexanes)

出典と根拠

ORDレコード
ord-1d619125794c498e8fc1f61b0fa699a2
出典データセット
uspto-grants-2016_08
特許番号
US09409892B2

反応ノート

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