Dichloromethane → Hydrochloric Acid
反応式
C([O:5][C:6](=[O:17])[CH:7]([C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)[CH2:8][NH2:9])(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)[Cl:26]>>[ClH:26].[NH2:9][CH2:8][CH:7]([C:10]1[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=1)[C:6]([OH:17])=[O:5]参加物
5
実験手順
A mixture of 3-amino-2-(4-fluoro-phenyl)-propionic acid tert-butyl ester (1.3 g) and TFA (10 mL) in DCM (10 mL) was stirred at rt for 1.5 h. Then concentrated, HCl aqueous solution (50 mL, 2 M) was added and concentrated; then acetonitrile was added, and concentrated; then ether was added, solids were collected via filtration and air dried to give HCl salt of 3-amino-2-(4-fluoro-phenyl)-propionic acid (1.21 g).
後処理
- concentrationThen concentrated
- additionHCl aqueous solution (50 mL, 2 M) was added
- concentrationconcentrated
- additionthen acetonitrile was added
- concentrationconcentrated
- additionthen ether was added
- filtrationsolids were collected via filtration and air
- customdried
出典と根拠
- ORDレコード
- ord-8369b4d45ea249f3840015022803296e
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09409892B2
反応ノート
読み込み中…