Triethylamine → Cyanomethyl 2-(allyloxy)acetate

2-(Allyloxy)acetic acid (0.500 g, 4.31 mmol) was dissolved in dichloromethane (20 ml), and 2-bromoacetonitrile (2.06 g, 17.18 mmol) and triethylamine (0.87 g, 8.61 mmol) were slowly added at room temperature. After stirring at room temperature for 3 hours, the reaction solution was concentrated under reduced pressure, and the resulting residue was purified by column chromatography (petroleum ether:ethyl acetate=20:1) to afford cyanomethyl 2-(allyloxy)acetate (0.40 g, 60%).

1. concentrationthe reaction solution was concentrated under reduced pressure
2. customthe resulting residue was purified by column chromatography (petroleum ether:ethyl acetate=20:1)

ORDレコード

ord-15b1999e72884665812c6f34cdce6047

出典データセット

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09409952B2