Lithium aluminum hydride → 2-(4-Chlorophenyl)-2-(pyrrolidin-1-yl)ethan-1-amine

HRID 1482489ノート

反応式

HRID 1482489 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[C:9]#[N:10])=[CH:4][CH:3]=1.[AlH4-].[Li+]>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([N:11]2[CH2:12][CH2:13][CH2:14][CH2:15]2)[CH2:9][NH2:10])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 28112Lithium aluminum hydrideHCID 24276601HCID 24276601、化合物

生成物 1

HCID 163948842-(4-Chlorophenyl)-2-(pyrrolidin-1-yl)ethan-1-amine収率 30%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (4-Chloro-phenyl)-pyrrolidin-1-yl-acetonitrile (3.52 g, 15.2 mmol; in Tetrahydrofuran (96 mL) was added Lithium tetrahydroaluminate (1225 mg, 32.28 mmol) and the reaction was refluxed over night. The reaction was quenched with H2O (1.22 ml), 2M NaOH (aq) (1.22 ml) and H2O (2.44 ml). The solid was filtered off and the reaction was concentrated, to yield 2-(4-chlorophenyl)-2-(pyrrolidin-1-yl)ethanamine (1.14 g, 30% yield).

後処理

  1. temperaturethe reaction was refluxed over night
  2. customThe reaction was quenched with H2O (1.22 ml), 2M NaOH (aq) (1.22 ml) and H2O (2.44 ml)
  3. filtrationThe solid was filtered off
  4. concentrationthe reaction was concentrated

出典と根拠

ORDレコード
ord-937bbc49f263452f84d3852305dc15bb
出典データセット
uspto-grants-2016_08
特許番号
US09415055B2

反応ノート

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