Ethyl Acetate → HCID 89389893、化合物
反応式
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:13][CH2:12][C@H:11]([C:14]([OH:17])([CH3:16])[CH3:15])[CH2:10]1)C1C=CC=CC=1.CC(=O)OCC>CCO.[OH-].[OH-].[Pd+2]>[NH2:8][C@H:9]1[CH2:13][CH2:12][C@H:11]([C:14]([OH:17])([CH3:16])[CH3:15])[CH2:10]1参加物
5
実験手順
A mixture of 2-(trans-3-(dibenzylamino)cyclopentyl)propan-2-ol (3 g, 9.3 mmol) and Pd(OH)2 (900 mg) in EtOH (30 mL) was hydrogenated under 50 psi of H2 for 48 h at room temperature. TLC (PE:EA=5:1) showed the reaction was complete. The mixture was filtered and concentrated in vacuo to give crude 2-(trans-3-aminocyclopentyl)propan-2-ol (1 g, 77%) as a yellow oil.
後処理
- filtrationThe mixture was filtered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-f5a31d661d0443e68b6cdd43e9ce8a61
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09416132B2
反応ノート
読み込み中…