Diisopropylethylamine → 2-(2-((6-Chlorohexyl)oxy)ethoxy)ethanamine

HRID 1483870ノート

反応式

HRID 1483870 の反応式
FC(F)(F)C([O-])=O.[Cl:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][NH3+:21].C(N(C(C)C)CC)(C)C>CN(C=O)C>[Cl:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][NH2:21]

参加物

4

反応物 2

HCID 81531DiisopropylethylamineHCID 866717092-[2-(6-Chlorohexyloxy)ethoxy]ethylammonium trifluoroacetate

生成物 1

HCID 100884642-(2-((6-Chlorohexyl)oxy)ethoxy)ethanamine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To one equivalent of the succinimidyl ester of the reporter group in DMF is added 3 equivalence of 2-[2-(6-chlorohexyloxy)-ethoxy]-ethyl-ammonium trifluoro-acetate stock solution, followed by diisopropylethylamine. The reaction is stirred from 8 to 16 hours at room temperature. Purification is accomplished by preparative scale HPLC or silica gel chromatography.

後処理

  1. customPurification

出典と根拠

ORDレコード
ord-77f9b530048a45bda0acec77e4668067
出典データセット
uspto-grants-2016_08
特許番号
US09416353B2

反応ノート

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