Sodium Hydroxide → 2-Pyrimidineacetic Acid
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][C:8]([O:10]CC)=[O:9].[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][C:8]([OH:10])=[O:9]参加物
4
実験手順
To a solution of ethyl 2-(pyrimidin-2-yl)acetate (Example 31b, 410 mg, 2.47 mmol) in ethanol (5 mL) was added 2N NaOH (2 mL) at room temperature under nitrogen. The reaction mixture was stirred at room temperature under nitrogen for 72 hours, then concentrated under reduced pressure. The residue was triturated with ethanol and concentrated under reduced pressure to give the title compound, which was carried onto the next step without further purification. MS 139 (MH+).
後処理
- concentrationconcentrated under reduced pressure
- customThe residue was triturated with ethanol
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-e89364df1dcf49d18d82f5b01474cf7d
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09420814B2
反応ノート
読み込み中…