Ammonium Hydroxide → (1E)-2-Phenylethenesulfonamide
反応式
[C:1]1(/[CH:7]=[CH:8]/[S:9](Cl)(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[NH4+:14]>C(#N)C>[C:1]1(/[CH:7]=[CH:8]/[S:9]([NH2:14])(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
3.3 g (1 mol equiv.) Trans-2-phenyl-ethenesulfonyl chloride was dissolved in 33 mL acetonitrile and cooled to 0° C. Dropwise, 7.7 mL (3 eq) ammoniumhydroxide was added and the reaction mixture was stirred at room temperature for 10 min. Volatiles were removed under reduced pressure, and the solid residue was washed with water and dried in vacuo to afford 1.13 g (38%) trans-2-phenyl-ethenesulfonic acid amide. 1H NMR (400 MHz, DMSO-d6) δ 7.11 (br.s., 2H), 7.23 (d, J=16.0 Hz, 1H), 7.31 (d, J=16.0 Hz, 1H), 7.41-7.45 (m, 3H), 7.64-7.71 (m, 2H).
後処理
- customVolatiles were removed under reduced pressure
- washthe solid residue was washed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-51f978050c6340a0a8939058920f86e7
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09422244B2
反応ノート
読み込み中…