Hydrogen Bromide → 2-(Bromomethyl)-5-(difluoromethoxy)-1,3-difluorobenzene

HRID 1484684ノート

反応式

HRID 1484684 の反応式
[F:1][CH:2]([F:14])[O:3][C:4]1[CH:9]=[C:8]([F:10])[C:7]([CH2:11]O)=[C:6]([F:13])[CH:5]=1.[BrH:15]>C(OCC)C>[Br:15][CH2:11][C:7]1[C:8]([F:10])=[CH:9][C:4]([O:3][CH:2]([F:14])[F:1])=[CH:5][C:6]=1[F:13]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 69140944Benzenemethanol, 4-(difluoromethoxy)-2,6-difluoro-

生成物 1

HCID 867324312-(Bromomethyl)-5-(difluoromethoxy)-1,3-difluorobenzene収率 67%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

162 mg [4-(difluoromethoxy)-2,6-difluorophenyl]methanol (0.769 mmol, 1.0 eq.) were dissolved in 0.348 mL hydrogen bromide (2.12 mmol, 2.8 eq.). and stirred at rt over night. The reaction mixture was diluted with diethylether and stirred for 5 minutes. The aqueous layer was washed twice with diethylether. The combined organic layers were washed with brine, dried over a silicon filter and concentrated in vacuo to provide the 149 mg (0.51 mmol, 67%) of the crude product, which was used without further purification.

後処理

  1. stirringstirred for 5 minutes
  2. washThe aqueous layer was washed twice with diethylether
  3. washThe combined organic layers were washed with brine
  4. customdried over a silicon
  5. filtrationfilter
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f4794655fd6a4886a308cec0c6a0f560
出典データセット
uspto-grants-2016_08
特許番号
US09422268B2

反応ノート

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