Water → HCID 84016145、化合物

HRID 1485028ノート

反応式

HRID 1485028 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH3:18])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5])C.[Li+].[OH-].O>C1COCC1.CO>[CH3:18][N:9]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]1

参加物

5

反応物 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 867185501-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester

生成物 1

HCID 84016145HCID 84016145、化合物

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.55 g; 91.37 mmol) was dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 182.73 mmol) was added. After 16 hours at ambient temperature the reaction mixture was washed with EtOAc. The aqueous layer was acidified with 1 N HCl and extracted with EtOAc which was dried and evaporated afterwards.

後処理

  1. washAfter 16 hours at ambient temperature the reaction mixture was washed with EtOAc
  2. extractionextracted with EtOAc which
  3. customwas dried
  4. customevaporated afterwards

出典と根拠

ORDレコード
ord-3d7606fdbb88412eade1017ed4fd0554
出典データセット
uspto-grants-2016_08
特許番号
US09422290B2

反応ノート

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