Trifluoroacetic acid → HCID 86718557、化合物
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:16]3[N:17]([C:30]([CH3:33])=[N:31][N:32]=3)[N:18]=[C:19]([N:21]([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH3:22])[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:23]([N:21]([CH3:22])[C:19]1[CH:20]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:16]2[N:17]([C:30]([CH3:33])=[N:31][N:32]=2)[N:18]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1参加物
4
実験手順
4-[6-(Benzyl-methyl-amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (4.08 g; 9.04 mmol) was dissolved in 20.0 ml of DCM and treated with 5.0 ml TFA. It was stirred at ambient temperature for 1 hour. The solution was concentrated under reduced pressure and the residue taken up in DCM and washed with half concentrated NaHCO3 solution. The organic phase was dried over MgSO4 and concentrated.