Trifluoroacetic acid → HCID 131736756、化合物

HRID 1485881ノート

反応式

HRID 1485881 の反応式
C(OC([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]1[C:17](=[O:27])[NH:18][C:19]1[C:24]([F:25])=[CH:23][CH:22]=[CH:21][C:20]=1[F:26])=O)(C)(C)C.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[F:31][C:30]([F:33])([F:32])[C:28]([OH:34])=[O:29].[F:26][C:20]1[CH:21]=[CH:22][CH:23]=[C:24]([F:25])[C:19]=1[NH:18][C:17]([CH:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:16][NH:8]1)=[O:27]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 90041044HCID 90041044、化合物

生成物 1

HCID 131736756HCID 131736756、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1-(2,6-difluoro-phenylcarbamoyl)-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester (460 mg, 1.23 mmol, Eq: 1.00) in CH2Cl2 (6 mL) was added TFA (2 mL) dropwise. The reaction was stirred at RT for 1 h. The solvent was evaporated to afford 2,3-dihydro-1H-isoindole-1-carboxylic acid (2,6-difluoro-phenyl)-amide trifluoroacetate which was used without further purification.

後処理

  1. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-642e4858cbbe4fa0a1f72c73dc82379d
出典データセット
uspto-grants-2016_08
特許番号
US09422332B2

反応ノート

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