2-(3-Fluoro-4-methoxyphenyl)ethanamine → 4-(2-Aminoethyl)-2-fluorophenol

HRID 14861ノート

反応式

HRID 14861 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH2:12])[CH:5]=[CH:6][C:7]=1[O:8]C>Br>[NH2:12][CH2:11][CH2:10][C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1

参加物

3

反応物 1

HCID 4263002-(3-Fluoro-4-methoxyphenyl)ethanamine

生成物 1

HCID 1932924-(2-Aminoethyl)-2-fluorophenol

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

実験手順

Intermediate 82 was dissolved in 200 mL of 48% aqueous HBr and the mixture heated to reflux for 2 hours. The Solvent was removed by rotary evaporation. The residue was taken up in 100 mL of ethanol and the solvent again removed. This was repeated twice more to remove residual water. LC-MS showed the product was >90% pure had the expected M+H+ of 156.

後処理

  1. temperaturethe mixture heated
  2. temperatureto reflux for 2 hours
  3. customThe Solvent was removed by rotary evaporation
  4. customthe solvent again removed
  5. customto remove residual water

出典と根拠

ORDレコード
ord-6c9988accec348ea9bff4032ff9d99e2
出典データセット
uspto-grants-2010_06
特許番号
US07732444B2

反応ノート

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