Dichloromethane → 2-(Chloromethyl)-1,3-difluoro-4-methoxybenzene
反応式
[F:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][CH:5]=[C:4]([F:10])[C:3]=1[CH2:11]O.[Cl:13]CCl>S(Cl)(Cl)=O>[Cl:13][CH2:11][C:3]1[C:2]([F:1])=[C:7]([O:8][CH3:9])[CH:6]=[CH:5][C:4]=1[F:10]参加物
4
実験手順
A solution of 120 mg (0.689 mmol) of 2,6-difluoro-3-methoxyphenyl)methanol from Example 132A in 3 ml of dichloromethane and 1 ml of thionyl chloride was stirred at room temperature overnight. The solvent was evaporated off under reduced pressure and the residue was purified by flash chromatography using a prepacked silica gel cartridge (eluent:cyclohexane-ethyl acetate 10:1 to 1:1), which gave 50 mg (38% of theory) of the target compound.
後処理
- customThe solvent was evaporated off under reduced pressure
- customthe residue was purified by flash chromatography
- customgave 50 mg (38% of theory) of the target compound
出典と根拠
- ORDレコード
- ord-49b063f191724ed6b57e4918eb30b772
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09422285B2
反応ノート
読み込み中…