Water → 1-Acridinamine

HRID 1486427

反応式

HRID 1486427 の反応式
N([C:4]1[C:5]2[C:10]([N:11]=[C:12]3[C:17]=1[CH:16]=[CH:15][CH:14]=[CH:13]3)=[CH:9][CH:8]=[CH:7][CH:6]=2)=C=S.CC(N)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H]([NH:43]C)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1.CC(NC)[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)CC1.C[C@@]1(O)[C@H](NC)[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H](N)C[C@H]2N)OC1.OS(O)(=O)=O.O.OS(O)(=O)=O>CO>[NH2:43][C:6]1[C:5]2[C:10](=[N:11][C:12]3[C:17]([CH:4]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:9]=[CH:8][CH:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 820909-IsothiocyanatoacridineHCID 9855350Gentamicin Sulfate

生成物 1

HCID 113521-Acridinamine収率 910.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒4 回

実験手順

9-Isothiocyanatoacridin (100 mg) was dissolved in MeOH (5 mL), and added to the solution of gentamicin sulfate (250 mg) in 5 mL MeOH and some drops of water, followed by the solution of BaO (100 mg) in 5 mL MeOH. The suspension was stirred 30 min, neutralized with 3% H2SO4 in MeOH, filtered, evaporated to dryness and the residue was washed carefully with dichloromethane. Obtained 297 mg of yellow powder.

後処理

  1. filtrationfiltered
  2. customevaporated to dryness
  3. washthe residue was washed carefully with dichloromethane

出典と根拠

ORDレコード
ord-5a66c58179864bdf88f5c0b726aeec75
出典データセット
uspto-grants-2016_08
特許番号
US09427406B2

関連ノート

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