Trichloroisocyanuric Acid → HCID 178469500、化合物

反応式

[CH2:1]1[CH2:11]CN2C(=NCCC2)CC1.[Br:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][C:17]([C:23](N)=[O:24])=[C:16]2[NH:26][C@H:27]1[CH2:30][C@@H:29]([O:31][CH3:32])[CH2:28]1.ClN1C(=[O:40])N(Cl)C(=O)N(Cl)C1=O>CO>[Br:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[N:19]=[CH:18][C:17]([C:23]([O:40][CH2:11][CH3:1])=[O:24])=[C:16]2[NH:26][C@H:27]1[CH2:30][C@@H:29]([O:31][CH3:32])[CH2:28]1

参加物

実験手順

DBU (5.36 mL, 35.86 mmol) was added in one portion to a mixture of 6-bromo-4-[(cis-3-methoxycyclobutyl)amino]quinoline-3-carboxamide (6.28 g, 17.93 mmol) and 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione (1.667 g, 7.17 mmol) in MeOH (65 mL). The resulting mixture was stirred at r.t. for 18 h. The resulting mixture was evaporated to dryness and the residue was purified by FCC, elution gradient 0 to 10% MeOH in DCM, to afford the desired material (6.48 g, 104%). Data consistent with material produced from alternate synthesis described earlier.