2,4-dimethyl-N-(2-methylpropyl)aniline → 4-bromo-N-(2,4-dimethylphenyl)-3,5-difluoro-N-isobutylbenzenesulfonamide

HRID 1487061ノート

反応式

HRID 1487061 の反応式
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([S:9](Cl)(=[O:11])=[O:10])=[CH:4][C:3]=1[F:13].[CH2:14]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:20]=1[CH3:26])[CH:15]([CH3:17])[CH3:16]>N1C=CC=CC=1>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([S:9]([N:18]([C:19]2[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][C:20]=2[CH3:26])[CH2:14][CH:15]([CH3:17])[CH3:16])(=[O:11])=[O:10])=[CH:4][C:3]=1[F:13]

参加物

4

反応物 2

HCID 284223892,4-dimethyl-N-(2-methylpropyl)anilineHCID 447175164-Bromo-3,5-difluorobenzenesulphonyl chloride

生成物 1

HCID 898759904-bromo-N-(2,4-dimethylphenyl)-3,5-difluoro-N-isobutylbenzenesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
20 °C

実験手順

To a solution of 4-bromo-3,5-difluorobenzene-1-sulfonyl chloride (1462 mg, 5.02 mmol) in pyridine (10 mL) at 20° C. was added N-isobutyl-2,4-dimethylaniline (889 mg, 5.01 mmol) and the reaction mixture was stirred at 20° C. for 2 hours. The reaction mixture was then evaporated in vacuo and redissolved in ethyl acetate. The organic phase was washed with saturated sodium carbonate (25 mL), dried using a hydrophobic frit and evaporated in vacuo to give the required product as a yellow oil, 2.06 g. LCMS [LCMS2] Rt 1.57 min, m/z (ES+) 432/434 (M+H).

後処理

  1. customThe reaction mixture was then evaporated in vacuo
  2. dissolutionredissolved in ethyl acetate
  3. washThe organic phase was washed with saturated sodium carbonate (25 mL)
  4. customdried
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-e36bc4801cae4e77bf7e2d48c28485fb
出典データセット
uspto-grants-2016_08
特許番号
US09428452B2

反応ノート

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