Triethylsilane → HCID 89815378、化合物

HRID 1487116ノート

反応式

HRID 1487116 の反応式
[F:1][C:2]([F:15])([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=1)[C:3]([NH2:5])=[O:4].C([SiH](CC)CC)C>CO.[Pd]>[NH2:12][C:8]1[CH:7]=[C:6]([C:2]([F:1])([F:15])[C:3]([NH2:5])=[O:4])[CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 2

HCID 12052TriethylsilaneHCID 89815111HCID 89815111、化合物

生成物 1

HCID 89815378HCID 89815378、化合物収率 69.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a stirred solution of 2,2-difluoro-2-(3-nitrophenyl)acetamide (0.5 g, 2.313 mmol) in methanol (20 ml) was added Pd—C (100 mg) followed by slow addition of triethylsilane (3.7 ml, 23.13 mmol) at RT. The reaction was stirred at same temperature for 30 min. The reaction mixture was filtered through celite bed and washed with methanol (50 ml). Filtrate was collected and concentrated under vacuum to get 2-(3-aminophenyl)-2,2-difluoroacetamide (0.301 g).

後処理

  1. filtrationThe reaction mixture was filtered through celite bed
  2. washwashed with methanol (50 ml)
  3. customFiltrate was collected
  4. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-e965fd3680d4426a8ddc72ce79c6bdb7
出典データセット
uspto-grants-2016_08
特許番号
US09428499B2

反応ノート

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