Triethylsilane → 3-((4-Methyl-1-piperazinyl)carbonyl)aniline

HRID 1487151ノート

反応式

HRID 1487151 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=2)=[O:9])[CH2:4][CH2:3]1.C([SiH](CC)CC)C>CO.[Pd]>[NH2:16][C:12]1[CH:11]=[C:10]([C:8]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[O:9])[CH:15]=[CH:14][CH:13]=1

参加物

5

反応物 2

HCID 12052TriethylsilaneHCID 763411(4-Methylpiperazin-1-yl)(3-nitrophenyl)methanone

生成物 1

HCID 167732183-((4-Methyl-1-piperazinyl)carbonyl)aniline収率 85%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a stirred solution of (4-methylpiperazin-1-yl)(3-nitrophenyl)methanone (5.5 g, 22.06 mmol) in MeOH (50 ml) was added Pd—C (10%, 0.470 g) followed by triethylsilane (14.10 ml, 88 mmol) (slow addition) at RT. The reaction mixture was stirred at same temperature for 25 min and filtered through celite, washed with methanol (50 ml). The Filtrate was concentrated under vacuum to get the title product (4.11 g).

後処理

  1. filtrationfiltered through celite
  2. washwashed with methanol (50 ml)
  3. concentrationThe Filtrate was concentrated under vacuum

出典と根拠

ORDレコード
ord-ec4c6f4b15364f1c9ba93fb08e74acc5
出典データセット
uspto-grants-2016_08
特許番号
US09428499B2

反応ノート

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