(S)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate → (S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid

HRID 1487174ノート

反応式

HRID 1487174 の反応式
[CH:1]([C:19]([O:21]CC1C=CC=CC=1)=[O:20])([C:9]([O:11]CC1C=CC=CC=1)=[O:10])[C@@H:2]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:3]>CO.[Pd]>[CH2:7]([O:6][C:4](=[O:5])[C@H:2]([CH:1]([C:19]([OH:21])=[O:20])[C:9]([OH:11])=[O:10])[CH3:3])[CH3:8]

参加物

4

反応物 1

HCID 86699671(S)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate

生成物 1

HCID 86699672(S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid収率 83%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To the solution of (S)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate (23 g, 0.06 mol) in methanol (500 mL) was added palladium on carbon (10%, 2 g), and then the mixture was stirred under an atmosphere of hydrogen at room temperature overnight. The catalyst was filtrated and the filtrate was concentrated under reduced pressure to afford the crude product (S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid, which was purified by silica gel chromatography (10 g, yield 83%).

後処理

  1. filtrationThe catalyst was filtrated
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f00957924cca487ab4b4d6a261d6ac4a
出典データセット
uspto-grants-2016_08
特許番号
US09428508B2

反応ノート

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