Isopropylamine → HCID 90161040、化合物
反応式
[Br:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:6]([C:8]([CH3:11])=[N:9][N:10]=2)[CH:7]=1.[CH:13]([NH2:16])([CH3:15])[CH3:14]>CN1C(=O)CCC1.O>[Br:1][C:2]1[N:3]=[C:4]([NH:16][CH:13]([CH3:15])[CH3:14])[C:5]2[N:6]([C:8]([CH3:11])=[N:9][N:10]=2)[CH:7]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
6-bromo-8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine J-1 (30.00 g; 121.2 mmol), isopropylamine (14.30 g; 242.44 mmol) and hünigbase (17.20 g; 133.33 mmol) are dissolved in 150 ml NMP and are stirred for 2 hours at 80° C. The reaction mixture is diluted with water and extracted with EtOAc. The organic layer is separated and dried over MgSO4 and evaporated to dryness.
後処理
- extractionextracted with EtOAc
- customThe organic layer is separated
- dry with materialdried over MgSO4
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-7625714b3e724b45b64374ae5950ddaa
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09428513B2
反応ノート
読み込み中…