Sodium Hydroxide → 1,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

HRID 1487272ノート

反応式

HRID 1487272 の反応式
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([CH3:11])[C:8](=[O:12])[N:7]([CH3:13])[CH:6]=1)=[O:4].[OH-].[Na+]>CO>[CH3:13][N:7]1[C:8](=[O:12])[C:9]([CH3:11])=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 117889483Methyl 1,5-dimethyl-6-oxopyridine-3-carboxylate

生成物 1

HCID 218859251,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
100 °C

実験手順

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester C-1 (2.60 g; 14.35 mmol) is suspended in MeOH. Sodium hydroxide (1 M solution, 45 ml; 45.00 mmol) is added and the reaction mixture is heated up to 100° C. (Drysyn, reflux) for 2 h. MeOH is removed under reduced pressure and 1N HCl (46 ml) is added to the solution, precipitation occurs. The precipitate is filtered off and dried under reduced pressure.

後処理

  1. temperature(Drysyn, reflux) for 2 h
  2. customMeOH is removed under reduced pressure and 1N HCl (46 ml)
  3. additionis added to the solution, precipitation
  4. filtrationThe precipitate is filtered off
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-0c64059cd1764151813a7a7f79d8bb53
出典データセット
uspto-grants-2016_08
特許番号
US09428515B2

反応ノート

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