Trifluoroacetic acid → benzyl (1-(5-(4-((1R,2S)-2-(2,2-difluoroacetamido)-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)ethyl)carbamate

HRID 1487551ノート

反応式

HRID 1487551 の反応式
FC(F)(F)C(O)=O.[F:8][CH:9]([F:46])[C:10]([N:12]1[C@H:16]([CH2:17][F:18])[C@@H:15]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:26]=[CH:27][C:28]([CH:31]([NH:33][C:34](=[O:43])[O:35][CH2:36][C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)[CH3:32])=[N:29][CH:30]=3)=[CH:21][CH:20]=2)[O:14]C1(C)C)=[O:11]>C(Cl)Cl>[F:46][CH:9]([F:8])[C:10]([NH:12][C@H:16]([CH2:17][F:18])[C@@H:15]([C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([CH:31]([NH:33][C:34](=[O:43])[O:35][CH2:36][C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[CH3:32])=[N:29][CH:30]=2)=[CH:23][CH:24]=1)[OH:14])=[O:11]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86695502HCID 86695502、化合物

生成物 1

HCID 86695504benzyl (1-(5-(4-((1R,2S)-2-(2,2-difluoroacetamido)-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)ethyl)carbamate収率 87.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Trifluoroacetic acid (2.2 mL) is added to the product of step 2, Example 95A (1.05 g, 1.94 mmol) in CH2Cl2 (39 mL) at 0° C. After 30 minutes the ice bath is removed and the mixture stirred at room temperature for 8 hours. Saturated NaHCO3 (60 mL) is added and the mixture extracted with CH2Cl2 (40 mL). The combined organics are dried over MgSO4, filtered and evaporated to give the title product (850 mg): m/z: 501.19.

後処理

  1. customAfter 30 minutes the ice bath is removed
  2. additionSaturated NaHCO3 (60 mL) is added
  3. extractionthe mixture extracted with CH2Cl2 (40 mL)
  4. dry with materialThe combined organics are dried over MgSO4
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-595f5de0b02a4d3c88fa9de079594761
出典データセット
uspto-grants-2016_08
特許番号
US09428528B2

反応ノート

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