Methanol → Methyl 2-chloro-4-thiazolecarboxylate

HRID 1487789ノート

反応式

HRID 1487789 の反応式
S(Cl)(Cl)=O.[Cl:5][C:6]1[S:7][CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=1.[CH3:14]O>>[Cl:5][C:6]1[S:7][CH:8]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[N:10]=1

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 218030262-Chloro-1,3-thiazole-4-carboxylic acid

生成物 1

HCID 7213135Methyl 2-chloro-4-thiazolecarboxylate収率 65%

実験手順

Thionyl chloride (4.4 mL, 61 mmol) was added dropwise to a solution of 2-chlorothiazole-4-carboxylic acid (2.00 g, 12.2 mmol) in MeOH (40 mL) at 0° C., and the reaction mixture was allowed to warm to rt. After stirring overnight, the reaction mixture was concentrated under reduced pressure. The resulting solid was recrystallized from EtOH/H2O (1:1), yielding 1.40 g (65%) of the title compound as an orange solid. LC-MS: RT=6.17 min, [M+H]+; =178.1.

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customThe resulting solid was recrystallized from EtOH/H2O (1:1)

出典と根拠

ORDレコード
ord-f13948313b6b40f2bf5200d093cd56b2
出典データセット
uspto-grants-2016_08
特許番号
US09428522B2

反応ノート

読み込み中…