Bromine → Methyl 5-(2-bromopropanoyl)-2,4-dimethylbenzoate
反応式
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:9]([C:13](=[O:16])[CH2:14][CH3:15])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[Br:17]Br>C(Cl)(Cl)Cl>[Br:17][CH:14]([CH3:15])[C:13]([C:9]1[C:10]([CH3:12])=[CH:11][C:2]([CH3:1])=[C:3]([CH:8]=1)[C:4]([O:6][CH3:7])=[O:5])=[O:16]参加物
4
反応条件
- 温度
- 20 °C
実験手順
Into a 100-mL round-bottom flask, was placed a solution of methyl 2,4-dimethyl-5-propionylbenzoate (compound 1.5, 600 mg, 2.72 mmol) in chloroform (20 mL). Bromine (154 μL, 3.00 mmol) was added and the resulting solution was stirred at 20° C. for 2 h. The mixture was concentrated under reduced pressure to yield the title compound as a yellow oil (1.0 g, crude), which was used in the next step without further purification.
後処理
- customInto a 100-mL round-bottom flask, was placed
- concentrationThe mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-9617a4ae3d504dbdb5bd0ac0f83b2b54
- 出典データセット
- uspto-grants-2016_08
- 特許番号
- US09428502B2
反応ノート
読み込み中…