Sodium Hydroxide → 3-(5-Chloro-2-methyl-1H-imidazol-4-yl)-4-methylbenzoic acid

HRID 1487847ノート

反応式

HRID 1487847 の反応式
[Cl:1][C:2]1[NH:6][C:5]([CH3:7])=[N:4][C:3]=1[C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[CH3:18])[C:11]([O:13]C)=[O:12].[OH-].[Na+]>CO>[Cl:1][C:2]1[NH:6][C:5]([CH3:7])=[N:4][C:3]=1[C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[CH3:18])[C:11]([OH:13])=[O:12]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 90030158Methyl 3-(5-chloro-2-methyl-1H-imidazol-4-yl)-4-methylbenzoate2 回

生成物 1

HCID 900302003-(5-Chloro-2-methyl-1H-imidazol-4-yl)-4-methylbenzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

A mixture of methyl 3-(5-chloro-2-methyl-1H-imidazol-4-yl)-4-methylbenzoate (compound 7.2, 10 mg, 0.038 mmol) in methanol (2 mL) and aqueous NaOH (2M, 0.2 mL, 0.4 mmol) was stirred at 50° C. for 16 hrs. The organic solvent was removed under reduced pressure and aqueous HCl (2 M) was added to the residue until a pH˜3-4 was attained. The solvents were removed under reduced pressure to produce a white solid which was a mixture of the title compound and salts and used in the next step without further purification. m/z (ES−) 249 (M−H)−.

後処理

  1. customThe organic solvent was removed under reduced pressure and aqueous HCl (2 M)
  2. additionwas added to the residue until a pH˜3-4
  3. customThe solvents were removed under reduced pressure
  4. customto produce a white solid which

出典と根拠

ORDレコード
ord-38bf2efa817d4226a254572e806cbe14
出典データセット
uspto-grants-2016_08
特許番号
US09428502B2

反応ノート

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