HCID 178494667、化合物 → HCID 178424688、化合物

反応式

C[O:2][CH2:3][C:4]1[NH:5][C:6]([C:10]2[C:11]([CH3:21])=[CH:12][C:13]([CH3:20])=[C:14]([CH:19]=2)[C:15]([O:17]C)=[O:16])=[C:7]([CH3:9])[N:8]=1>Br>[OH:2][CH2:3][C:4]1[NH:5][C:6]([C:10]2[C:11]([CH3:21])=[CH:12][C:13]([CH3:20])=[C:14]([CH:19]=2)[C:15]([OH:17])=[O:16])=[C:7]([CH3:9])[N:8]=1

参加物

反応条件

温度: 80 °C

実験手順

Into a 100-mL round-bottom flask, was placed methyl 5-(2-(methoxymethyl)-4-methyl-1H-imidazol-5-yl)-2,4-dimethylbenzoate (compound 222.4, 220 mg, 0.76 mmol) and HBr (20 mL, 40% in HOAc). The reaction mixture was stirred overnight at 80° C. The resulting mixture was concentrated under reduced pressure. This resulted in 190 ma (crude) of the title compound as a brown solid.

後処理

customInto a 100-mL round-bottom flask, was placed
concentrationThe resulting mixture was concentrated under reduced pressure

出典と根拠

ORDレコード: ord-11a9c9d7ef35491db59acab365b86621
出典データセット: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09428502B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 178494667HCID 178494667、化合物2 回

生成物 1

HCID 178424688HCID 178424688、化合物

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

反応条件

温度: 80 °C

実験手順

後処理

customInto a 100-mL round-bottom flask, was placed
concentrationThe resulting mixture was concentrated under reduced pressure

出典と根拠

ORDレコード: ord-11a9c9d7ef35491db59acab365b86621
出典データセット: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09428502B2

反応ノート

読み込み中…