HCID 178494681、化合物 → HCID 178424690、化合物

反応式

[Cl:1][C:2]1[N:3]=[C:4]([CH2:19][O:20]C)[NH:5][C:6]=1[C:7]1[C:8]([CH3:18])=[CH:9][C:10]([CH3:17])=[C:11]([CH:16]=1)[C:12]([O:14]C)=[O:13]>Br>[Cl:1][C:2]1[N:3]=[C:4]([CH2:19][OH:20])[NH:5][C:6]=1[C:7]1[C:8]([CH3:18])=[CH:9][C:10]([CH3:17])=[C:11]([CH:16]=1)[C:12]([OH:14])=[O:13]

参加物

反応条件

温度: 90 °C

実験手順

Into a 50-mL round-bottom flask, was placed a solution of methyl 5-(4-chloro-2-(methoxymethyl)-1H-imidazol-5-yl)-2,4-dimethylbenzoate (compound 230.5, 20 mg, 0.06 mmol) in HBr (5 mL, 40% in AcOH). The reaction mixture was stirred overnight at 90° C. The resulting mixture was concentrated under reduced pressure. This resulted in 10 mg (55%) of the title compound as a yellow crude solid.

後処理

customInto a 50-mL round-bottom flask, was placed
concentrationThe resulting mixture was concentrated under reduced pressure

出典と根拠

ORDレコード: ord-a5a41ad08db44c28b87b83c900cf2d5a
出典データセット: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09428502B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 178494681HCID 178494681、化合物2 回

生成物 1

HCID 178424690HCID 178424690、化合物収率 59.4%

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

反応条件

温度: 90 °C

実験手順

後処理

customInto a 50-mL round-bottom flask, was placed
concentrationThe resulting mixture was concentrated under reduced pressure

出典と根拠

ORDレコード: ord-a5a41ad08db44c28b87b83c900cf2d5a
出典データセット: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09428502B2

反応ノート

読み込み中…