Hydrazine hydrate (1:1) → HCID 178430911、化合物

HRID 1488169ノート

反応式

HRID 1488169 の反応式
C(O/[CH:4]=[C:5](\[CH3:12])/[C:6](=O)[C:7]([F:10])([F:9])[F:8])C.O.[NH2:14][NH2:15]>CCO>[CH3:12][C:5]1[C:6]([C:7]([F:10])([F:9])[F:8])=[N:14][NH:15][CH:4]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 10997657(3E)-4-ethoxy-1,1,1-trifluoro-3-methylbut-3-en-2-one2 回

生成物 1

HCID 178430911HCID 178430911、化合物収率 93.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

Into a 100-mL round-bottom flask, was placed (E)-4-ethoxy-1,1,1-trifluoro-3-methylbut-3-en-2-one (compound 261.1, 2.6 g, 14.3 mmol) in EtOH (20 mL). Hydrazine hydrate (1.8 mL, 38 mmol) was added and the resulting solution was stirred for 2 h at 80° C. The reaction was concentrated under reduced pressure to obtain the title compound as a yellow oil (2 g, crude).

後処理

  1. customInto a 100-mL round-bottom flask, was placed
  2. concentrationThe reaction was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-8ee4985915c64c7e9fd2fd372f022501
出典データセット
uspto-grants-2016_08
特許番号
US09428502B2

反応ノート

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