反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]#[N:11].[Li]CCCC.CCCCCC.[Cl:23][C:24]1[CH:45]=[C:44]([C:46]([F:49])([F:48])[F:47])[CH:43]=[CH:42][C:25]=1[O:26][C:27]1[CH:28]=[CH:29][C:30]([N+:39]([O-:41])=[O:40])=[C:31]([CH:38]=1)[O:32][CH:33]([CH3:37])[C:34](Cl)=[O:35].Cl>O1CCCC1>[Cl:23][C:24]1[CH:45]=[C:44]([C:46]([F:47])([F:48])[F:49])[CH:43]=[CH:42][C:25]=1[O:26][C:27]1[CH:28]=[CH:29][C:30]([N+:39]([O-:41])=[O:40])=[C:31]([CH:38]=1)[O:32][CH:33]([CH3:37])[C:34](=[O:35])[CH:9]([C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[Cl:1])[C:10]#[N:11]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
反応条件
- 温度
- -78 °C
実験手順
A solution of 0.93 g of 2,4-dichlorophenylacetonitrile in 30 ml of anhydrous tetrahydrofuran (hereinafter abbreviated as "THF") was cooled to -78° C. To this solution was added 3.5 ml of a 1.6Mn BuLi-hexane solution. Then, a THF solution of 2.12 g of 2-[5-(2-chloro-4-trifluoromethylphenoxy)-2-nitrophenoxy]propionic acid chloride was added thereto dropwise. The mixed solution was stirred for 30 minutes, then acidified with a 10% hydrochloric acid aqueous solution, and extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous magnesium sulfate, filtered and concentrated with a rotary evaporator.
後処理
- extractionextracted with ethyl acetate
- dry with materialThe ethyl acetate layer was dried over anhydrous magnesium sulfate
- filtrationfiltered
- concentrationconcentrated with a rotary evaporator
出典と根拠
- ORDレコード
- ord-67b52b8b130a4511a6c1240f92044ef8
- 出典データセット
- uspto-grants-1997_10
- 特許番号
- US05674811
関連ノート
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