Ethanol → ethyl (chloroethoxy)formate

To a solution of chloroethyl chloroformate (23.16 g, 0.162 mol) and ethanol (7.45 g, 0.162 mol) in methylene chloride (200 ml), pyridine (12.82 g, 0.162 mol) was added at 0° C. After 10 min at 0° C. and 21 hours at 25° C. the reaction mixture was washed with aqueous hydrochloric acid (100 ml), aqueous saturated sodium hydrogen carbonate (100 ml) and water (100 ml). The solvent was removed under reduced pressure after drying (MgSO4), giving 18.5 g (74%) of the intermediate ethyl chloroethyl carbonate as a crude product.

1. wash21 hours at 25° C. the reaction mixture was washed with aqueous hydrochloric acid (100 ml), aqueous saturated sodium hydrogen carbonate (100 ml) and water (100 ml)
2. customThe solvent was removed under reduced pressure
3. dry with materialafter drying (MgSO4)

ORDレコード

ord-618e3eb8611b41aba61114ec66b17a41

出典データセット

uspto-grants-1997_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05676925