m-Chloroperbenzoic acid → 3-(4-phenylthiazol-2-yl)pyridine-N-oxide

HRID 1489237ノート

反応式

HRID 1489237 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:2]=1.ClC1C=CC=C(C(OO)=[O:26])C=1>ClCCl>[C:12]1([C:10]2[N:11]=[C:7]([C:3]3[CH:2]=[N+:1]([O-:26])[CH:6]=[CH:5][CH:4]=3)[S:8][CH:9]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 7010154-Phenyl-2-(pyridin-3-yl)thiazole

生成物 1

HCID 187071743-(4-phenylthiazol-2-yl)pyridine-N-oxide収率 28.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In 50 ml of dichloromethane was dissolved 1 g of 2-(pyridin-3-yl)-4-phenylthiazole. Thereto was added 900 mg of m-chloroperbenzoic acid at room temperature. The mixture was stirred at the same temperature for 2 hours. The reaction mixture was washed with an aqueous sodium hydrogencarbonate solution and dried. The solvent was removed by distillation. The residue was recrystallized from ethyl acetate to obtain 306 mg of 3-(4-phenylthiazol-2-yl)pyridine-N-oxide as a brown powder.

後処理

  1. washThe reaction mixture was washed with an aqueous sodium hydrogencarbonate solution
  2. customdried
  3. customThe solvent was removed by distillation
  4. customThe residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-0d4d97c01f5c4160a41867accee9bad3
出典データセット
uspto-grants-1997_10
特許番号
US05677319

反応ノート

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