Thionyl Chloride → 3-(2-Biphenylyl)-2-ethylpropionyl chloride

HRID 1489313

反応式

HRID 1489313 の反応式
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH:8]([CH2:12][CH3:13])[C:9](O)=[O:10].S(Cl)([Cl:22])=O>>[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH:8]([CH2:12][CH3:13])[C:9]([Cl:22])=[O:10]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 215719833-(2-Biphenylyl)-2-ethylpropionic acid

生成物 1

HCID 223402173-(2-Biphenylyl)-2-ethylpropionyl chloride収率 106.3%

実験手順

To a 100-ml three-necked round flask (equipped with stirrer chip, Dimroth condenser, thermometer and NaOH trap) were introduced 13.3 g (52.4 mmol) of the 3-(2-biphenylyl)-2-ethylpropionic acid and 25.9 ml (355 mmol) of thionyl chloride, and they were refluxed for 2.5 hours with heating in a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 15.2 g of a crude product of yellow orange liquid. This acid chloride was used for the next reaction without further purification. The properties of the product thus obtained are described below.

後処理

  1. customTo a 100-ml three-necked round flask (equipped with stirrer chip, Dimroth condenser
  2. temperaturewere refluxed for 2.5 hours
  3. temperaturewith heating in a nitrogen atmosphere
  4. distillationthe unreacted thionyl chloride was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-ca9642abf1f94eaca83a79f5b40c43cb
出典データセット
uspto-grants-1997_10
特許番号
US05677408

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